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Aspergillus nigermetabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4

โœ Scribed by Kyung Myung; John A. Manthey; Jan A. Narciso

Publisher
Springer
Year
2008
Tongue
English
Weight
212 KB
Volume
78
Category
Article
ISSN
1432-0614

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## Abstract The cytochrome P450 enzyme cytochrome P450 3A4 (CYP3A4) controls the metabolism of about 60% of all drugs, and its inhibition may dramatically affect drug safety. Modulation of cytochrome P450 activity has been observed by constituents of fruit extracts including several flavonoids. The