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Aspergillosis in bone marrow transplant recipients

โœ Scribed by P.L. Ho; K.Y. Yuen

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
131 KB
Volume
34
Category
Article
ISSN
1040-8428

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โœฆ Synopsis

Invasive aspergillosis in bone marrow transplant recipient is associated with a high mortality. Diagnosis is often delayed because the inflammatory response is blunted by immunosuppression. The gold standard of tissue biopsy is often considered too in invasive as the procedure is often complicated by bleeding and secondary infection. Recent finding on non-invasive tests such as serial measurement of peripheral blood galactomannan antigen or DNA appears to be promising. However, the limited availability of such tests and requirement for expertise are still hampering their use in routine clinical management. More often

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Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation
โœ Dimitrios P. Kontoyiannis; Georgios Chamilos; Russell E. Lewis; Sergio Giralt; J ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 77 KB ๐Ÿ‘ 2 views

## Abstract ## BACKGROUND. Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation. Laboratory studies have demonstrated that iron is essential for __Aspergillus__ growth and virulence. ## METHODS. In