Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement

✍ Scribed by Nichola J. Coleman; Kunle Awosanya; John W. Nicholson

• Book ID: 102295406
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 393 KB
• Volume: 90A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.32070

✦ Synopsis

Abstract

In response to a burgeoning interest in the prospective clinical applications of hydraulic calcium (alumino)silicate cements, the in vitro bioactivity and dissolution characteristics of a white Portland cement have been investigated. The formation of an apatite layer within 6 h of contact with simulated body fluid was attributed to the rapid dissolution of calcium hydroxide from the cement matrix and to the abundance of pre‐existing SiOH nucleation sites presented by the calcium silicate hydrate phase. A simple kinetic model has been used to describe the rate of apatite formation and an apparent pseudo‐second‐order rate constant for the removal of HPO~4~^2−^ ions from solution has been calculated (k~2~ = 5.8 ×10^−4^ g mg^−1^ min^−1^). Aspects of the chemistry of hydraulic cements are also discussed with respect to their potential use in the remedial treatment of living tissue. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009