Aspects actuels de la cryptococcose neuroméningée chez des sujets adultes infectés par le VIH dans le service de médecine interne du CHU de Treichville d’Abidjan (Côte d’Ivoire)

✍ Scribed by K. Kadjo; B. Ouattara; K.D. Adoubryn; O. Kra; E.K. Niamkey

• Publisher: Masson Editeur
• Year: 2011
• Tongue: French
• Weight: 162 KB
• Volume: 21
• Category: Article
• ISSN: 1156-5233
• DOI: 10.1016/j.mycmed.2010.11.007

✦ Synopsis

Objectives:

To determine the prevalence of neuromeningeal cryptococcosis (nmc) and reporting sociodemographic, clinical, paraclinical aspects and outcome of patients.

Methods:

It was a retrospective study concerning 22 hiv positive patients hospitalized between 2006 to and 2009 in the internal medicine service of university hospital of treichville for nmc.

Results:

The prevalence of nmc in patients infected with hiv was 0.6%. the mean age was 35±4.5 years old. the sex-ratio was 0.5. the average time evolution of the symptomatology was 10±2.1 days. the installation of the disease was progressive (86.4%). the main signs were fever (100%) and headache (95.4%). the cerebrospinal fluid was inflammatory aspect (95.4%) with low glucose (91%), hyper lymphocytosis(100%). there were cryptococcus neoformans in direct exam by china ink (72.7%) and culture on sabouraud (100%). treatment was injectable amphoterin b in monotherapy (54.5%) followed by fluconazole per os (45.5%). the mortality was 54.5%.

Conclusion:

This study shows a reduction of nmc prevalence in our service in relation with tritherapy.