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Aspartate buffer and divalent metal ions affect oxytocin in aqueous solution and protect it from degradation

โœ Scribed by Avanti, Christina; Oktaviani, Nur Alia; Hinrichs, Wouter L.J.; Frijlink, Henderik W.; Mulder, Frans A.A.


Book ID
123303475
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
921 KB
Volume
444
Category
Article
ISSN
0378-5173

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A New Strategy to Stabilize Oxytocin in
โœ Christina Avanti; Jean-Pierre Amorij; Dewi Setyaningsih; Andrea Hawe; Wim Jiskoo ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› American Association of Pharmaceutical Scientists ๐ŸŒ English โš– 316 KB

In the current study, the effect of metal ions in combination with buffers (citrate, acetate, pHย 4.5) on the stability of aqueous solutions of oxytocin was investigated. Both monovalent metal ions (Na^+^ and K^+^) and divalent metal ions (Ca^2+^, Mg^2+^, and Zn^2+^) were tested all as chloride salts