Aspartame prevents the karyomegaly induced by ochratoxin A in rat kidney
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- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 331 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0340-5761
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π SIMILAR VOLUMES
The nephrotoxic/carcinogenic mycotoxin ochratoxin A (OTA) occurs as a contaminant in food and feed and may be linked to human endemic Balkan nephropathy. The mechanism of OTA-derived carcinogenicity is still under debate, since reactive metabolites of OTA and DNA adducts have not been unambiguously
Ochratoxin A (OTA), a naturally occurring mycotoxin produced by Aspergillus and Penicillium genera, blocks anion conductance in Madin-Darby canine kidney (MDCK) cells and reduces the potassium concentration gradient in the same cells. So far, a direct effect of OTA on cation channels has not been re