✦ LIBER ✦

Aspartame dipeptide analogues: effect of number of side-chain methylene group spacers and Cα-methylation in the second position

✍ Scribed by Eric Mossel; Fernando Formaggio; Marco Crisma; Claudio Toniolo; Quirinus B. Broxterman; Wilhelmus H.J. Boesten; Johan Kamphuis; Peter J.L.M. Quaedflieg; Piero Temussi

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 620 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(97)00127-4

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✦ Synopsis

Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartame analogues in which the L-Phe 2 residue is replaced by L-(c~Me)Phg, L-(c~Me)Phe or L-(otMe)Hph. The analogues containing either the first or the third Ca-methylated, phenyl-containing~ residue in the second position of the dipeptide were synthesized and found to be approximately as sweet as aspartame itself and its L-(~xMe)Phe 2 analogue.