ASP – a simulation-based power calculator for genetic linkage studies of qualitative traits, using sib-pairs

Power and robustness of a score test for

Power and robustness of a score test for linkage analysis of quantitative traits using identity by descent data on sib pairs

✍ Darlene R. Goldstein; Sandrine Dudoit; Terence P. Speed 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 2 views

## Abstract Identification of genes involved in complex traits by traditional (lod score) linkage analysis is difficult due to many complicating factors. An unfortunate drawback of non‐parametric procedures in general, though, is their low power to detect genetic effects. Recently, Dudoit and Speed