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ASNA-1 Positively Regulates Insulin Secretion in C. elegans and Mammalian Cells

✍ Scribed by Gautam Kao; Cecilia Nordenson; Maria Still; Agneta Rönnlund; Simon Tuck; Peter Naredi


Book ID
116353360
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
908 KB
Volume
128
Category
Article
ISSN
0092-8674

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## Abstract Impairment of glucose‐stimulated insulin secretion (GSIS) caused by glucolipotoxicity is an essential feature in type 2 diabetes mellitus (T2DM). Palmitate and eicosapentaenoate (EPA), because of their lipotoxicity and protection effect, were found to impair or restore the GSIS in beta