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Ascorbic acid inhibits osteoclastogenesis of RAW264.7 cells induced by receptor activated nuclear factor kappaB ligand (RANKL)in vitro

✍ Scribed by Xiao, X. H.; Liao, E. Y.; Zhou, H. D.; Dai, R. C.; Yuan, L. Q.; Wu, X. P.


Book ID
125335951
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
313 KB
Volume
28
Category
Article
ISSN
0391-4097

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## Abstract Proliferation and differentiation of osteoclasts are regulated by a cytokine system that includes RANKL, which binds 2 receptors: RANK, which activates osteoclast differentiation, and osteoprotegerin (OPG), a decoy receptor that limits RANKL action. We investigated the role of the OPG/R