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Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice

✍ Scribed by Akiko Amano; Toshiro Aigaki; Naoki Maruyama; Akihito Ishigami

Book ID
116178579
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
430 KB
Volume
496
Category
Article
ISSN
0003-9861

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Sodium-dependent vitamin C transporter 2
Sodium-dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L-ascorbic acid into Schwann cells
✍ Burkhard Gess; Christina Lohmann; Hartmut Halfter; Peter Young 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB

## Abstract Ascorbic acid has been shown to be an essential component for __in vitro__ myelination and to improve the clinical and pathological phenotype of a mouse model of Charcot–Marie‐tooth disease 1A. The mechanism of ascorbic acid uptake into peripheral nerves, however, has not been addressed