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Ascorbate as an Alternative to Thiol Additives in Native Chemical Ligation

✍ Scribed by Heike Rohde; Josephine Schmalisch; Ziv Harpaz; Franziska Diezmann; Prof. Dr. Oliver Seitz

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 216 KB
Volume: 12
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.201100179

No coin nor oath required. For personal study only.

✦ Synopsis

Among the segment coupling methods used for the chemical synthesis of proteins, [1] native chemical ligation is one of the most powerful and most widely applied reactions. [2] This method provided a major boost to chemical protein sciences, as can be inferred from the increasing amount of publications in which native chemical ligation is employed to construct biologically active proteins. The approach involves a peptide thioester such as 1 (Scheme 1) and an N-terminal cysteinyl peptide

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