## Abstract Fibrosis in glomerulosclerosis causes progressive loss of renal function. Transforming growth factor (TGF)‐β, one of the major profibrotic cytokines, induces the synthesis of plasminogen activator inhibitor (PAI)‐1, a factor that plays a crucial role in the development of fibrosis. Here
✦ LIBER ✦
Ascochlorin suppresses TGF-β1-induced PAI-1 expression through the inhibition of phospho-EGFR in rat kidney fibroblast cells
✍ Scribed by Hyun-Ji Cho; Jeong-Han Kang; Ji-Hak Jeong; Yun-Jeong Jeong; Kwan-Kyu Park; Yoon-Yub Park; Yong-Suk Moon; Hong-Tae Kim; Il-Kyung Chung; Cheorl-Ho Kim; Hyeun-Wook Chang; Young-Chae Chang
- Book ID
- 106471531
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 328 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0301-4851
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## Abstract Ascochlorin, a non‐toxic prenylphenol compound derived from the fungus __Ascochyta viciae__, has been shown recently to have anti‐cancer effects on various human cancer cells. However, the precise molecular mechanism of this anti‐cancer activity remains to be elucidated. Here, we invest