Epidemiologic studies suggest increased risk of epithelial ovarian cancer in female asbestos workers and increased risk of malignancy in general in household contacts of asbestos workers. Ovaries were studied ,from 13 women with household contact with men with documented asbestos exposure and from I7 women undergoing incidental oophorectomv. Ovarian tissue w*as examined by analytic electron microscopy.
Significant asbestos fiber burdens were detected in 9 out of 13 women with household asbestos exposure (69.2%), and in 6 out of I7 women who gave no exposure history (35%). Three exposed women had asbestos counts over I millioii fibers per gram wet weight (23%). but onlv 1/17 women without an exposure history had a count that high (6%). Although asbestos has been documented as a contaminant of some older cosmetic talc preparations, the chrysotile and cmcidolite types of asbestos we detected are more indicative of background ari&or occupational exposure.
This study demonstrates that asbestos can reach the ovary. Although the number of subjects is small, asbestos appears to be present in ovarian tissue niorr ,frequently and in higher atnounts in women with a documentable exposure history. 0 I996 WiIev-Liss, /nc.