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Arylmethyl esters as protecting groups for carboxylic, carbonic and carbamic acids: deprotection via homogeneous palladium-catalyzed hydrogenolysis

✍ Scribed by André Boutros; Jean-Yves Legros; Jean-Claude Fiaud

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
206 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

4-Quinolylmethyl (4-QUI) esters of carboxylic acids and 1-naphthyimethyi (1-NAP) esters of carbonic and carbamic acids are reduced by palladium-catalyzed hydrogenolysis by formate anion. The reaction conditions are compatible with the presence of a benzyl ester and of an alkene double bond.

📜 SIMILAR VOLUMES

4-Quinolylmethyl and 1-Naphthylmethyl as
4-Quinolylmethyl and 1-Naphthylmethyl as Benzyl-type Protecting Groups of Carboxylic Acids Removable by Homogeneous Palladium-Catalyzed Hydrogenolysis
✍ André Boutros; Jean-Yves Legros; Jean-Claude Fiaud 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 243 KB

AbstractÐ4-Quinolylmethyl (4-QUI) esters are reduced by palladium-catalyzed hydrogenolysis by formate anion. The reaction conditions are compatible with reducible substituents or functional groups as aromatic bromo, alkene, aldehyde, ketone, nitrile, ethyl and benzyl esters. An allyl ester is cleave