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Arylamine spider toxins antagonize NMDA receptor-mediated synaptic transmission in rat hippocampal slices

โœ Scribed by Alan L. Mueller; Benedict C. Albensi; Alan H. Ganong; Linda S. Reynolds; Hunter Jackson

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
649 KB
Volume
9
Category
Article
ISSN
0887-4476

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โœฆ Synopsis

The effects of arylamine spider toxins on synaptic transmission in rat hippocampal slices were investigated. Two different responses were monitored: the AMPA receptor-mediated population spike recorded in control buffer (selectively antagonized by DNQX) and the NMDA receptor-mediated EPSP recorded in nominally magnesium-free buffer containing 20 pM DNQX (selectively antagonized by AP5, AP7, and dizocilpine (MK-801)). The synthetic arylamine spider toxins JSTX-3, argiotoxin-636, and argiotoxin-659 were 26 to 73 times more potent at antagonizing the NMDA receptor-mediated EPSP values ranging from 12 to 24 FM) than the AMPA receptor-mediated population spike (IC,O values ranging from 612 to 878 pM). These results indicate that arylamine spider toxins are selective antagonists of NMDA receptors in the mammalian CNS.

Argiotoxins, Glutamate receptors, AMPA @ 1991 WILEY-LISS, INC.

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