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Aryl hydrocarbon receptor regulates lipopolysaccharide-induced inflammatory responses

✍ Scribed by Akihiro Kimura; Tetsuji Naka; Taisuke Nakahama; Ichino Chinen; Kazuya Masuda; Tadamitsu Kishimoto

Book ID
116399227
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
61 KB
Volume
48
Category
Article
ISSN
1043-4666

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## Abstract β‐Arrestins are scaffolding proteins implicated as negative regulators of TLR4 signaling in macrophages and fibroblasts. Unexpectedly, we found that β‐arrestin‐1 (β‐arr‐1) and ‐2 knockout (KO) mice are protected from TLR4‐mediated endotoxic shock and lethality. To identify the potential