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Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis

✍ Scribed by Jennifer L. Marlowe; Alvaro Puga

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
169 KB
Volume
96
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Most effects of exposure to halogenated and polycyclic aromatic hydrocarbons are mediated by the aryl hydrocarbon receptor (AHR). It has long been recognized that the AHR is a ligand‐activated transcription factor that plays a central role in the induction of drug‐metabolizing enzymes and hence in xenobiotic detoxification. Of late, it has become evident that outside this well‐characterized role, the AHR also functions as a modulator of cellular signaling pathways. In this Prospect, we discuss the involvement of the AHR in pathways critical to cell cycle regulation, mitogen‐activated protein kinase cascades, immediate‐early gene induction, and the functions of the RB protein. Ultimately, the toxicity of AHR xenobiotic ligands may be intrinsically connected with the perturbation of these pathways and depend on the many critical signaling pathways and effectors with which the AHR itself interacts. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.

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