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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

โœ Scribed by Boitano, Anthony E. (author);Wang, Jian (author);Romeo, Russell (author);Bouchez, Laure C. (author);Parker, Albert E. (author);Sutton, Sue E. (author);Walker, John R. (author);Flaveny, Colin A. (author);Perdew, Gary H. (author);Denison, Michael S. (author);Schultz, Peter G. (author);Cooke, Michael P. (author)


Book ID
111945618
Publisher
American Association for the Advancement of Science
Year
2010
Tongue
English
Weight
619 KB
Volume
329
Category
Article
ISSN
0036-8075

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In vivo, stem cell factor (SCF) exists in both a bound and soluble isoform. It is believed that the bound form is more potent and fundamentally required for the maintenance of hematopoietic stem cells (HSCs). This theory is supported by the observation that steel-Dickie mice lacking the bound isofor