Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
โ Scribed by Boitano, Anthony E. (author);Wang, Jian (author);Romeo, Russell (author);Bouchez, Laure C. (author);Parker, Albert E. (author);Sutton, Sue E. (author);Walker, John R. (author);Flaveny, Colin A. (author);Perdew, Gary H. (author);Denison, Michael S. (author);Schultz, Peter G. (author);Cooke, Michael P. (author)
- Book ID
- 111945618
- Publisher
- American Association for the Advancement of Science
- Year
- 2010
- Tongue
- English
- Weight
- 619 KB
- Volume
- 329
- Category
- Article
- ISSN
- 0036-8075
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๐ SIMILAR VOLUMES
In vivo, stem cell factor (SCF) exists in both a bound and soluble isoform. It is believed that the bound form is more potent and fundamentally required for the maintenance of hematopoietic stem cells (HSCs). This theory is supported by the observation that steel-Dickie mice lacking the bound isofor