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Aryl hydrocarbon hydroxylase activity in human lung tissue: In relation to cigarette smoking and lung cancer


Book ID
123157211
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
154 KB
Volume
11
Category
Article
ISSN
0169-5002

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## Abstract In both the rat kidney and lung, inhalation of cigarette smoke diluted with air (1/15) for a limited period of time (15 min) specifically induces aryl hydrocarbon hydroxylase (AHH)<2> in less than 4 h. Up to four successive inhalations administered at 2โ€h intervals additively induce bot

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Aryl hydrocarbon hydroxylase (AHH) activity was measured fluorometrically in surgically-excised fresh lung tissue, pulmonary alveolar macrophages (PAMs), and peripheral blood lymphocytes from 14 cigarette smokers (7 with and 7 without primary lung cancer). Levels of AHH in fresh PAMs and AHH inducib