Aryl hydrocarbon hydroxylase activity in human lung tissue: In relation to cigarette smoking and lung cancer
- Book ID
- 123157211
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 154 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0169-5002
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The inducibility of aryl hydrocarbon hydroxylase (AHH) activity in peripheral mitogen-treated lymphocytes, and of AHH and other monoxygenase activities in lung samples, was studied in 41 patients-34 with pulmonary carcinoma, 4 with a benign lung tumour and 3 with chronic obstructive pulmonary diseas
## Abstract In both the rat kidney and lung, inhalation of cigarette smoke diluted with air (1/15) for a limited period of time (15 min) specifically induces aryl hydrocarbon hydroxylase (AHH)<2> in less than 4 h. Up to four successive inhalations administered at 2โh intervals additively induce bot
Aryl hydrocarbon hydroxylase (AHH) activity was measured fluorometrically in surgically-excised fresh lung tissue, pulmonary alveolar macrophages (PAMs), and peripheral blood lymphocytes from 14 cigarette smokers (7 with and 7 without primary lung cancer). Levels of AHH in fresh PAMs and AHH inducib