Aryl-derivatized, water-soluble functionalized carbon nanotubes for biomedical applications

✍ Scribed by N. Karousis; H. Ali-Boucetta; K. Kostarelos; N. Tagmatarchis

• Book ID: 104063808
• Publisher: Elsevier Science
• Year: 2008
• Tongue: English
• Weight: 484 KB
• Volume: 152
• Category: Article
• ISSN: 0921-5107
• DOI: 10.1016/j.mseb.2008.06.002

✦ Synopsis

The functionalization of very-thin multi-walled carbon nanotubes (VT-MWNTs) with an aniline derivative, via the protocol of in situ generated aryl diazonium salts results, upon acidic deprotection of the terminal BOC group, on the formation of the water-soluble positively charged ammonium functionalized VT-MWNTs-NH 3 + material. The new materials have been structurally and morphologically characterized by infra-red (ATR-IR) spectroscopy and transmission electron microscopy (TEM). The quantitative calculation of the grafted aryl units onto the skeleton of VT-MWNTs has been estimated by thermogravimetric analysis (TGA), while the quantitative Kaiser test showed the amine group loaded onto VT-MWNTs-NH 3 + material. The aqueous solubility of this material has allowed the performance of some initial toxicological in vitro investigations.