Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure−Activity Relationships
✍ Scribed by Glase, Shelly A.; Akunne, Hyacinth C.; Heffner, Thomas G.; Jaen, Juan C.; MacKenzie, Robert G.; Meltzer, Leonard T.; Pugsley, Thomas A.; Smith, Sarah J.; Wise, Lawrence D.
- Book ID
- 126423368
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 304 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
1,2,3,6-Tetrahydr0-4-[U-1~C]phenylpyridine (12) was synthesized and coupled to (R)-3-phenyl-3-cyclohexene-1-carboxylic acid to make the titled compound 2 in 21% overall yield. Purification considerations were an important factor in the choice of a reaction sequence to 2, and successful synthesis was
## Abstract Fourteen novel __N__‐(substituted phenylcarbonylamino)‐4‐ethyl‐1,2,3,6‐tetrahydropyridines **9** were synthesized in fair to good yields. 4‐Ethylpyridine **5** reacted with __O__‐mesitylenesulfonylhydroxylamine (__O__‐MSH) **4** to furnish __N__‐amino‐4‐ethylpyridinium mesitylenesulfona