Artificial Transcription Factors which Mediate Double-Strand DNA Cleavage
✍ Scribed by Chao Li; Chao Du; Hua Tian; Chao Jiang; Min Du; Yan Liu; Prof. Ren-Zhong Qiao; Prof. Yan-Xing Jia; Prof. Yu-Fen Zhao
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 400 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0947-6539
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✦ Synopsis
Abstract
A new family of artificial transcription factor (ATF)‐based conjugates have been designed and synthesized as potent chemical nucleases. Polyamides as the important and efficient ATFs were used to modify and activate several anchor compounds. The results demonstrate that the resulting conjugates remarkably promote the rate accelerations and non‐random double‐strand DNA cleavage activity. Interestingly, the cleavage activity of both the hydrolytic and oxidative agents was promoted efficiently through the modification of the ATFs.