✦ LIBER ✦

Artificial skin I. Preparation and properties of pluronic F-127 gels for treatment of burns

✍ Scribed by Schmolka, Irving R.

Publisher: John Wiley and Sons
Year: 1972
Tongue: English
Weight: 518 KB
Volume: 6
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820060609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The preparation of block polymer surface‐active agents derived solely from propylene oxide and ethylene oxide is described. The physical properties of a nonionic surfactant of 12,500 molecular weight, Pluronic F‐127, are presented. The toxicity data of the polymeric series is reviewed. The preparation of cold aqueous solutions of the F‐127 solution, to which silver salts and other medicaments are then added, is described. By raising the temperature, these fluid liquids are then converted to strong “ringing” gels or viscous ointments which are suitable for application to a burn wound or abraded skin area. The factors involved in altering the yield strength of the gel are presented.

📜 SIMILAR VOLUMES

Pluronic F-127 gel preparation as an art

Pluronic F-127 gel preparation as an artificial skin in the treatment of third-degree burns in pigs

✍ Nalbandian, Robert M. ;Henry, Raymond L. ;Balko, Kenneth W. ;Adams, Dennis V. ;N 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 898 KB

A blinded study was designed to provide qualitative and quantitative evaluation on the possible therapeutic benefits of the use of Pluronic@ Polyol F-127 as a substitute skin in standardized third-degree thermal burns. Three separate burns, approximately 1600 mm2, were induced on the shaved backs of

Artifical skin. II. Pluronic F-127 silve

Artifical skin. II. Pluronic F-127 silver nitrate or silver lactate gel in the treatment of thermal burns

✍ Nalbandian, Robert M. ;Henry, Raymond L. ;Wilks, Harvey S. 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 1 views

## Abstract Pluronic F‐127 was found to be an effective base for the bactriocidal agent silver nitrate or silver lactate following 18–22% surface area full thickness thermal burns. Some protection was afforded by Pluronic F‐127 alone, attesting to its biological activity as an artificial skin. The