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Artificial rearing alters the response of rats to natural and drug-mediated rewards

✍ Scribed by Anna M. Lomanowska; Shadna A. Rana; Dawn McCutcheon; Linda A. Parker; Patricia E. Wainwright

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 188 KB
Volume: 48
Category: Article
ISSN: 0012-1630
DOI: 10.1002/dev.20139

No coin nor oath required. For personal study only.

✦ Synopsis

Artificial rearing (AR) of infant rats permits precise control over key features of the early environment without maternal influence. The present study examined the behavioral response of AR rats towards natural and drug-mediated rewards, as well as their exploratory and affective behaviors. Adolescent AR rats showed increased preference for sucrose consumption relative to chow and demonstrated greater activity in the open field and in the elevated plus-maze compared to maternally reared (MR) rats. With respect to measures of emotionality, AR rats showed enhanced avoidance of the open arms of the plus-maze, indicating increased anxiety, but they did not differ from MR rats in exploring the center of the open field. Adult AR rats displayed a stronger conditioned response to morphine in a place preference test. These findings support the potential of the AR model to contribute to understanding the role of early experience in the development of behavioral motivation.

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