Artificial metastases and decrease of fibrinolysis in the nude mouse lung after hemithoracic irradiation

✍ Scribed by Hideki Hirata; Kenzo Tanaka

• Book ID: 104635784
• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 496 KB
• Volume: 2
• Category: Article
• ISSN: 0262-0898
• DOI: 10.1007/bf00135170

✦ Synopsis

X-irradiation to the nude mouse lung and the ensuing pulmonary metastasis of the injected human cancer cells were investigated. Human cancer cells were injected intravenously into nude mice following 20Gy right hemithoracic irradiation. The right lungs showed evidence of metastasis while metastasis was slight in the non-irradiated left lung. Platelet aggregation and fibrin deposition occurred around the arrested cancer cells m the capillaries of the right lung. The fibrmolytlc actlvltx of the irradiated right lung ~as lo~er than that of the nonirradiated contralateral lung. Natural killer cell activity was lower in the rightlung-irradiated mice than in the non-irradiated mice. We conclude that when the target organ is exposed to X-irradiation, there will be a decrease in fibrinolytic activity, a condition paving the way toward a metastasis.

Materials and methods

Cancer cells

Human squamous cell carcinoma of the lung, PC9 with high fibrinolytic activity and low thromboplastic activity, and QG56 with moderate fibrinolytic activity and