Artificial mammalian gene regulation networks—novel approaches for gene therapy and bioengineering
✍ Scribed by Wilfried Weber; Martin Fussenegger
- Book ID
- 119524256
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 882 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0168-1656
No coin nor oath required. For personal study only.
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## Background: Rheumatoid arthritis is characterized by inflammation of the synovial tissue. high systemic doses are necessary to achieve therapeutic levels of anti-rheumatic drugs in the joints. gene transfer might provide a more efficient delivery system for genes encoding therapeutic proteins.
Most conditional expression vectors designed for mammalian cells have been valuable systems for studying genes of interest by regulating their expressions. The available vectors, however, are reliable for the short-length cDNA clones and not optimal for relatively long fragments of genomic DNA or lo