Articular cartilage repair by gene therapy using growth factor–producing mesenchymal cells

Repair of articular cartilage defect by

Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene–transduced chondrocytes with adeno-associated virus vector

✍ Naoki Yokoo; Tomoyuki Saito; Masaaki Uesugi; Naomi Kobayashi; Ke-Qin Xin; Kenji 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB

## Abstract ## Objective To examine the effects of basic fibroblast growth factor (bFGF) gene–transduced chondrocytes on the repair of articular cartilage defects. ## Methods LacZ gene or bFGF gene was transduced into primary isolated rabbit chondrocytes with the use of a recombinant adeno‐assoc