[Article] Score tests of genetic association in the presence of linkage based on the additive genetic gamma frailty model
✍ Scribed by Zhong X., Li H.
- Book ID
- 127404896
- Year
- 2004
- Tongue
- English
- Weight
- 183 KB
- Category
- Library
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## Abstract In testing genetic linkage using large or complex pedigrees, robust methods may be preferred to the Lod‐score method. The affected‐pedigree‐member method is robust but does not use the information available in nonaffected subjects, which results in a loss of power. We propose a new test
## Abstract Family‐based association tests (FBATs) provide simple and powerful tests to detect association between a genetic marker and a disease‐susceptibility locus, manifest in subjects by a phenotype or disease trait. Here we propose a new class of conditional tests for family‐based association