Arthropathy in juvenile hemochromatosis

✍ Scribed by George Vaiopoulos; George Papanikolaou; Marianna Politou; Iyad Jibreel; Nikos Sakellaropoulos; Dimitris Loukopoulos

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 79 KB
• Volume: 48
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.10755

✦ Synopsis

Objective:

To evaluate whether arthropathy is associated with juvenile hemochromatosis and, if so, to assess the relationship between this feature and other clinical features of the disease.

Methods:

Clinical, laboratory, and radiologic evidence of arthropathy was studied in 8 greek patients with genetically proven juvenile hemochromatosis. osteopenia and osteoporosis were assessed by bone mineral density measurement.

Results:

Seven of the 8 patients had articular manifestations. the main affected joint was the metacarpophalangeal joint, and the arthritis was progressive independent of phlebotomy therapy. osteopenia was observed in 2 patients, and osteoporosis in 2 patients.

Conclusion:

Arthropathy may be present in patients with juvenile hemochromatosis, with features similar to those found in patients with hemochromatosis type 1.