Arthritis rounds. A case of congenital insensitivity to pain with neuropathic arthropathy
β Scribed by Vert Mooney; Henry J. Mankin
- Publisher
- John Wiley and Sons
- Year
- 1966
- Tongue
- English
- Weight
- 801 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0004-3591
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π SIMILAR VOLUMES
Point mutations affecting the NTRK1/TRKA gene, encoding one of the receptors for the nerve growth factor (NGF), have been detected in congenital insensitivity to pain with anhidrosis (CIPA), a human hereditary sensory neuropathy characterized by absence of reaction to noxious stimuli and anhidrosis.
Congenital insensitivity to pain with anhidrosis is an autosomal recessive hereditary disorder characterized by recurrent episodic fever, anhidrosis (inability to sweat), absence of reaction to noxious stimuli, self-mutilating behavior, and mental retardation. The human TRKA gene (NTRK1), located on