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Arthritis induced by systemic autoimmunity against glucose-6-phosphate isomerase in normal mice

✍ Scribed by T Kamradt, L Bruns, O Frey, L Morawietz, D Schubert…

Book ID
120706510
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
148 KB
Volume
9
Category
Article
ISSN
1478-6354

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## Abstract ## Objective Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose‐6‐phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients.