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Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan

✍ Scribed by Sakina B Elamin, Elfatih M Malik, Tarig Abdelgadir, Ammar H Khamiss…


Book ID
120687510
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
516 KB
Volume
4
Category
Article
ISSN
1475-2875

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Chloroquine can no longer be recommended as the first-line treatment for falciparum malaria in several parts of Africa, given the increasing resistance of Plasmodium falcipanrm to this drug. The sulfadoxinepyrimethamine combination (SP) is obviously an alternative candidate, that has already been se

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Artemisinin derivatives, such as artesunate, have a short half-life and very rapid anti-malarial activity. Theoretically, using such agents in conjunction with well-established anti-malarial drugs such as sulfadoxine-pyrimethamine may reduce the rate of drug resistance. Such a combination has not pr