✍ Scribed by Kang, Qian K. ;An, Yuehuei H. ;Moreira, Patricia L. ;Demcheva, Marina V. ;Vournakis, John N.
No coin nor oath required. For personal study only.
Aqueous solutions of poly‐N‐acetyl glucosamine (p‐GlcNAc) exhibit a liquid‐gel transition at physiological pH and temperature. This feature inspired the authors to conduct a study to evaluate the macro‐ and histological changes of rat kidneys after embolization using either p‐GlcNAc gel injection into the renal artery or ligation of the renal artery. The procedures were performed in 46 rats through open abdominal surgeries. Animals were sacrificed at 3 days and at 1, 3, 5, and 8 weeks postoperatively. The results of both macro‐observation and histological study showed that p‐GlcNAc gels were effective in causing necrosis and subsequent fibrosis in all embolized kidneys. The data indicate that p‐GlcNAc gel may have promise as an effective agent for therapeutic embolization. © 2005 Wiley‐Liss, Inc.
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