Artemisinin–quinoline hybrid-dimers: Synthesis and in vitro antiplasmodial activity
✍ Scribed by Marli C. Lombard; David D. N’Da; Jaco C. Breytenbach; Peter J. Smith; Carmen A. Lategan
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 176 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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We have synthesized a series of six nonsteroidal homo-and heterobifunctional estrogenic dimers designed for the treatment of breast cancer. They are made of two triphenylethylene moieties linked by an aliphatic chain. The synthesis used six steps, from the known alcohol 5, with an overall yield of m
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