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Arsenic Trioxide with Ascorbic Acid and High-Dose Melphalan: Results of a Phase II Randomized Trial

โœ Scribed by Muzaffar H. Qazilbash; Rima M. Saliba; Yago Nieto; Gaurav Parikh; Matteo Pelosini; Fatima B. Khan; Roy B. Jones; Chitra Hosing; Floralyn Mendoza; Donna M. Weber; Michael Wang; Uday Popat; Amin Alousi; Paolo Anderlini; Richard E. Champlin; Sergio Giralt


Book ID
116280460
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
356 KB
Volume
14
Category
Article
ISSN
1083-8791

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Phase II study of arsenic trioxide and a
โœ JE Chang; PM Voorhees; JM Kolesar; HG Ahuja; FA Sanchez; GA Rodriguez; K Kim; J ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 115 KB ๐Ÿ‘ 1 views

Arsenic trioxide (As 2 O 3 ) has established clinical activity in acute promyelocytic leukaemia and has pre-clinical data suggesting activity in lymphoid malignancies. Cell death from As 2 O 3 may be the result of oxidative stress. Agents which deplete intracellular glutathione, such as ascorbic aci