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Arsenic-induced Aurora-A activation contributes to chromosome instability and tumorigenesis

✍ Scribed by Wu, Chin-Han; Tseng, Ya-Shih; Yang, Chao-Chun; Kao, Yu-Ting; Sheu, Hamm-Ming; Liu, Hsiao-Sheng


Book ID
123108273
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
381 KB
Volume
77
Category
Article
ISSN
0743-9547

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## Abstract Arsenic is a known human carcinogen. However, the mechanism of how arsenic induces cell transformation remains unclear. In this study, we demonstrated that long‐term exposure to sodium arsenite at low‐dose (2 ¡M) increases cell proliferation and neoplastic transformation in a mouse epid