Arrested development: Understanding v-abl

✍ Scribed by Lawrence D. Kerr

• Book ID: 101712651
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 388 KB
• Volume: 16
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.950160702

✦ Synopsis

The protein tyrosine kinase activity of the v-abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation. Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre-B cell stage. Recent reports have characterized these cells expressing high v-abl kinase activity as deficient in detectable NF-KB DNA binding activity and low level RAG gene expression. These observations suggest that v-ubl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway.