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Array Comparative Genomic Hybridization Copy Number Profiling: A New Tool for Translational Research in Solid Malignancies

✍ Scribed by José Luis Costa; Gerrit Meijer; Bauke Ylstra; Carlos Caldas

Book ID
113900709
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
857 KB
Volume
18
Category
Article
ISSN
1532-9461

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Array comparative genomic hybridization
Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer
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## Abstract Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumor predisposition syndrome with cutaneous and uterine leiomyomatosis as well as renal cell cancer (RCC) as its clinical manifestations. HLRCC is caused by heterozygous germline mutations in the __fumarate hydratase (fumaras