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Aromatic β-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists

✍ Scribed by Yongli Du; Qunyi Li; Bing Xiong; Xin Hui; Xin Wang; Yang Feng; Tao Meng; Dingyu Hu; Datong Zhang; Mingwei Wang; Jingkang Shen

Book ID
108072848
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
926 KB
Volume
18
Category
Article
ISSN
0968-0896

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Non-steroidal 1-methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalenes and acyclic derivatives were evaluated as novel series of progesterone receptor (PR) antagonists using the T47D cell alkaline phosphatase assay. Moderate to potent PR antagonists were achieved with these scaffolds. Se