Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit

✍ Scribed by Ryuuta Fukutomi; Aya Tanatani; Hiroki Kakuta; Nobuo Tomioka; Akiko Itai; Yuichi Hashimoto; Koichi Shudo; Hiroyuki Kagechika

• Book ID: 104259758
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 244 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01378-1

✦ Synopsis

Tetraguanidines (1 and 2) with an aromatic multilayered structure exhibit potent binding to a specific site of DNAs with binding constants of the order of 107 M ~ as deduced from Scatchard analysis of ultrafiltration data and simulation of CD titration curves. NMR spectra of the complexes indicated that 1 and 2 bind DNAs sequence-specifically at the minor groove, as predicted by computational docking studies.