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Aromatic hydroxylation and catechol formation: A novel metabolic pathway of the growth promotor zeranol

โœ Scribed by Andreas Hildebrand; Erika Pfeiffer; Manfred Metzler


Book ID
119381808
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
843 KB
Volume
192
Category
Article
ISSN
0378-4274

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๐Ÿ“œ SIMILAR VOLUMES


Aromatic hydroxylation is a major metabo
โœ Erika Pfeiffer; Andreas Hildebrand; Georg Damm; Andreas Rapp; Benedikt Cramer; H ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 869 KB

## Abstract Zearalenone (ZEN) is a common mycotoxin, for which only reductive metabolites have been identified so far. We now report that ZEN is extensively monohydroxylated by microsomes from human liver __in vitro__. Two of the major oxidative metabolites arise through aromatic hydroxylation and