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Aromatic compounds as allosteric inhibitors of glycogen phosphorylase b

โœ Scribed by G. Soman; George Philip

Book ID
115733731
Publisher
Elsevier Science
Year
1974
Weight
199 KB
Volume
358
Category
Article
ISSN
0005-2744

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Alteration of the intramolecular dynamic
Alteration of the intramolecular dynamics of glycogen phosphorylase b by allosteric ligands
โœ ร. Szarka; E. Gabellieri; M. Gonnelli; P. Cioni; Zs. Lakos; B. Somogyi ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 551 KB

Phosphorylase 6 (E.C. 2.4.1.1), prepared from rabbit skeletal muscle, was used to study whether the binding of allosteric ligands modifies the intramolecular dynamics of the protein matrix. Protein dynamics were monitored through the fluorescence and phosphorescence parameters of the 12 tryptophan (