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Aromatase inhibitors in the breast cancer clinic: focus on exemestane

โœ Scribed by Van Asten, K.; Neven, P.; Lintermans, A.; Wildiers, H.; Paridaens, R.


Book ID
127013408
Publisher
Bioscientifica
Year
2014
Tongue
English
Weight
327 KB
Volume
21
Category
Article
ISSN
1351-0088

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Estrogens are the major hormones supporting the growth of human breast cancer. Aromatization of androgen precursors in peripheral tissues, including the breast cancer itself, is the major source of estrogens in postmenopausal women. Therefore, inhibition of the aromatase enzyme offers an effective m