Aromatase inhibitor therapy: toxicities and management strategies in the treatment of postmenopausal women with hormone-sensitive early breast cancer
β Scribed by Susan F. Dent; Rania Gaspo; Michelle Kissner; Kathleen I. Pritchard
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 537 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0167-6806
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Five years of adjuvant therapy with tamoxifen was considered the gold-standard treatment for postmenopausal women with estrogen receptor-positive breast cancer for many years. Data from a core group of clinical trials investigating the safety and efficacy of aromatase inhibitors (AIs) have challenge
## Abstract ## BACKGROUND. Despite the advantages from using aromatase inhibitors (AIs) compared with tamoxifen for early breast cancer, an unexpectedly greater number of grade 3 and 4 cardiovascular events (CVAE) (as defined by National Cancer Institute of CanadaβCommon Toxicity Criteria [version