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Argyrophilic nucleolar organizer regions in breast carcinoma. Correlation with dna flow cytometry, histopathology, and lymph node status

โœ Scribed by Walid A. Mourad; Bayzar Erkman-Balis; Sandra Livingston; Mohamed Shoukri; Charles E. Cox; Santo V. Nicosia; David T. Rowlands Jr


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
626 KB
Volume
69
Category
Article
ISSN
0008-543X

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Argyrophilic nucleolar organizer regions
โœ Kumar, Anand; Kushwaha, Anand Kumar; Kumar, Mohan; Gupta, Saroj ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 87 KB ๐Ÿ‘ 2 views

Background and Objectives: Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer.

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Human breast carcinomas (n = 232) were evaluated for estrogen and progesterone receptors (ER, PR) by immunohistochemical study and by cytosol steroid-binding assay (n = 185). The staining was scored (histoscore) by estimates of relative nuclear staining intensity and the percentage of positively sta