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Arginine-vasopressin in congenital nephrogenic diabetes insipidus

✍ Scribed by Bichet, D.


Book ID
121956271
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
149 KB
Volume
43
Category
Article
ISSN
0753-3322

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X-linked recessive nephrogenic diabetes insipidus is caused by mutations in the gene encoding the V2 vasopressin receptor (V2R), the mediator of the antidiuretic effect of arginine vasopressin (AVP) in mammalian kidneys. Upon binding to AVP, the receptor activates the G protein G s , stimulating a p