Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery

Arginine-rich cell penetrating peptides:

Arginine-rich cell penetrating peptides: Design, structure–activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides

✍ R. Abes; A. Arzumanov; H. Moulton; S. Abes; G. Ivanova; M. J. Gait; P. Iversen; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB

## Abstract Rerouting the splicing machinery with steric‐block oligonucleotides (ON) might lead to new therapeutic strategies in the treatment of diseases such as β‐thalassemia, Duchenne muscular dystrophy, or cancers. Interfering with splicing requires the sequence‐specific and stable hybridizatio