Arginine depletion as a mechanism for the immune privilege of corneal allografts

Covalent modification as a mechanism for

Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse

✍ Jeremy M. Palmer; Amanda J. Robe; Alastair D. Burt; John A. Kirby; David E. J. J 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 395 KB 👁 1 views

The autoimmune liver disease primary biliary cirrhosis (PBC) is characterized by the breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC). How tolerance is broken to such a central and highly conserved self antigen in the initiation of autoimmunity remains unclear. One p