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Arginase II inhibited lipopolysaccharide-induced cell death by regulation of iNOS and Bcl-2 family proteins in macrophages

✍ Scribed by Lee, Eun Ji; Lee, Yu Ran; Joo, Hee Kyoung; Cho, Eun Jung; Choi, Sunga; Sohn, Kyung-Cheol; Lee, Sang Do; Park, Jin Bong; Jeon, Byeong Hwa

Book ID: 120284108
Publisher: Korean Society for Molecular and Cellular Biology
Year: 2013
Tongue: English
Weight: 605 KB
Volume: 35
Category: Article
ISSN: 1016-8478
DOI: 10.1007/s10059-013-2332-7

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## Abstract In vivo administration of the mitochondrial inhibitor 3‐nitropropionic acid (3‐NP) produces striatal pathology mimicking Huntington's disease (HD). However, the mechanisms of cell death induced by metabolic impairment are not fully understood. Previous studies showed that 3‐NP triggered